H. pylori Picture Book

This page will be added to as we have time.

Click on the thumbnails to see the complete picture. High resolution images (suitable for publication) can be obtained for a modest charge. The fee helps support this internet site. Email for more information.

CAD pic jpg of HP 49k A to scale (x 10,000) CAD drawing of an HP courtesy of Luke Marshall Please contact Luke directly for copyright permission and hi-res 3d animations of this organism.
CAD pic jpg of HP 49k A more accurate version of the to scale (x 10,000) CAD drawing of an HP courtesy of Luke Marshall . Please contact Luke directly for copyright permission and hi-res 3d animations of this organism.
This is a picture of a tiny gastric biopsy being removed from the forceps. The biopsy can be tested for urease enzyme to detect the HP. Click here for more about the urease test.
Gram stain of HP This is a 3 day culture of HP on blood agar.
silver stain of HP A silver stain (Warthin Starry) of HP (black wiggly things) on gastric mucus-secreting epithelial cells (x1000). This picture is notorious because it is of Dr. Marshall's stomach biopsy taken 8 days after he drank a culture of H. pylori. The experiment was published in 1985 (Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfill Koch's postulates for pyloric Campylobacter. Med J Aust 1985; 142: 436-439).
This is a x1000 photograph of HP in an antral gland. Ths picture and more details of the patient's history were published in the NEJM as "picture of the week". Congratulations to Drs. Bob Genta and David Graham of the Veteran's Affairs Hospital in Houston Texas.
Antral biopsy gif This is a normal antral biopsy. It was taken from a healthy young Virginian doctor who bravely volunteered for endoscopy.
Antral biopsy inflamed gif This is a H&E stained section of an inflamed (infected with H.pylori) gastric antral biopsy (x250). The lamina propria (area under the mucus epithelial cells) is shown. Most of the cells are lymphocytes or plasma cells (chronic inflammation). Glands may be reduced. A few neutrophils are seen invading glands (active or acute inflammation). Neutrophils are also called polymorphonuclear leucocytes because they have lobulated nuclei.
This is a Period Acid - Schiff (PAS) stain of duodenal mucosa. In it you can see delicate pink brush-border intestinal mucosa (bottom center) moving up to heavy gastric type epithelium (center left vertical with clear area to the left of it) then changing back to intestinal type with goblet cells and a gland at top center. The presence of the gastric type mucosa allows attachment of HP in the duodenum and subsequent development of duodenal ulcer.

HOME PAGE

© B.J.Marshall Feb 13, 1998: All rights reserved